It's the last time the Grizzlies will face the Raptors this season, but their first meeting with Toronto since Memphis traded Rudy Gay north of the border.
The Grizzlies didn't let emotion play any part of the meeting, taking down the Raptors and their former teammate 88-82.
Zach Randolph had 17 points and 18 rebounds, and Mike Conley 17 points as the Grizzlies won their fifth straight game.
The win snaps Toronto's five game winning streak. Rudy Gay had 13 points on just 5 of 15 shooting against his former team in the loss.
Tony Allen scored 12 points and Tayshaun Prince had 11 as the Grizzlies won for the eighth time in nine meetings with the Raptors and posted their fourth straight win in Toronto.
Memphis returns home Friday night against Orlando.