Titans quarterback Jake Locker is out for the season with a foot injury.
Locker left in the second quarter of Sunday's loss to the Jags, pulling up lame on a handoff to Chris Johnson.
Locker has a Lisfranc injury, damage to a ligament that stabilizes the mid-foot, and may need surgery
The Titans have a short week to get backup Ryan Fitzpatrick ready.
Tennessee will host division leader Indianapolis on Thursday.