A traffic accident on I-40 near Canada Road caused a major back-up on both the eastbound and westbound sides of the highway.
A spokesperson with the Shelby County Fire Department said one person was airlifted from the scene of the accident to a local hospital. Another victim was transported from the scene by ambulance.
Witnesses said a car crossed the highway median and struck a vehicle traveling in the opposite direction.
The ensuing back-up snared I-40 traffic for more than an hour, as officials worked to transport the victims and clear the accident from the highway.